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O-Desmethyl PKC412
PubMed Central PMCID: PMC4479529
consistent with an inhibition of both mTORC1 and mTORC2 complexes
2019 Dec 9
cell-based screening using rodent pancreatic β cells
FH535 - CAS# 108409-83-2 size:2mg solid O-Desmethyl PKC412FH535, CAS No. 108409 83 2, is a catenin pathway inhibitor. FH535 represses pancreatic cancer xenograft growth and angiogenesis. FH535 increases the radiosensitivity and reverses epithelial to mesenchymal transition of radioresistant esophageal cancer cell line KYSE 150R. FH535 inhibited metastasis and growth of pancreatic cancer cells. FH535 selectively inhibits cell proliferation and potentiates imatinib induced apoptosis in myeloid leukemia cell
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