RBN-2397 Catalog No.:M26339-C 3S)-2-[(2S)-2-amino-3-phenylpropanamido]-3-methylpentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-methylbutanamido]-N-({[(1S)-1-carbamoyl-4-[(diaminomethylidene)amino]butyl]carbamoyl}methyl)hexanamide

3S)-2-[(2S)-2-amino-3-phenylpropanamido]-3-methylpentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-methylbutanamido]-N-({[(1S)-1-carbamoyl-4-[(diaminomethylidene)amino]butyl]carbamoyl}methyl)hexanamide

once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice

InChi: InChI=1S/C21H20N2O3S/c24-21(22-15-17-7-3-1-4-8-17)19-11-13-20(14-12-19)27(25

A number of substrates have been identified

41) and (4

RBN-2397 Catalog No.:M26339-C 3S)-2-[(2S)-2-amino-3-phenylpropanamido]-3-methylpentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-methylbutanamido]-N-({[(1S)-1-carbamoyl-4-[(diaminomethylidene)amino]butyl]carbamoyl}methyl)hexanamideRBN 2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN 2397 selectively binds to PARP7 (Kd=0. 001 M) and restores IFN signaling. RBN 2397 has the potential for the study of advanced or metastatic solid tumors. Product information CAS Number: 2381037 82 5 Molecular Weight: 523. 43 Formula: C20H23F6N7O3 Chemical Name: 5 {[(2S) 1 (3 oxo 3 {4 [5 (trifluoromethyl)pyrimidin 2 yl]piperazin 1