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InChiKey: SMZYCXAYGPGYRS-NGTUZWGPSA-N
Smiles: O=C(NCC1C=CN=CC=1)[C@]12C[C@@]3(C[C@H](C1)C[C@@H](C3)C2)C1C=CC(Cl)=CC=1
It also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells
0 μM for A498
CAS Number: 503612-47-3
Vinflunine tartrate Ivabradine Hydrochloride InChiKey: SMZYCXAYGPGYRS-NGTUZWGPSA-NVinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.
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