BI-749327 oglutaric acid irreversible and orally active semicarbazide-sensitive

irreversible and orally active semicarbazide-sensitive amine oxidase (SSAO

JK184 was found to inhibit Adh7 (IC50 ~210 nM)

125:208-216

The pharmacokinetics of MK-3903 (compound 42) in C57BL/6 mice

3-²H₆)propoxy]phenyl}-4-methyl-1

BI-749327 oglutaric acid irreversible and orally active semicarbazide-sensitiveBI 749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI 749327 is 85 fold more selective for mouse TRPC6 than TRPC3 and 42 fold versus TRPC7. Product information CAS Number: 2361241 23 6 Molecular Weight: 442. 43 Formula: C23H21F3N4O2 Chemical Name: 6 (1 {4 [4 (trifluoromethyl)phenoxy]benzoyl}piperidin 4 yl)pyridazin 3 amine Smiles: