Tyk2-IN-5 ino pyrazole is a activin receptor-like kinase-2

is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1

3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide (2R

CRA-026440 inhibits pure recombinant isozymes HDAC1

InChi: InChI=1S/C11H19N4O7P/c1-9-12-6-11(15(16)17)14(9)8-10(22-23(18

InChi: InChI=1S/C69H102N12O16S/c1-14-43(8)60(51(94-12)38-55(85)80-35-20-24-50(80)61(95-13)44(9)62(87)75-49(66-71-34-36-98-66)37-45-21-16-15-17-22-45)78(10)67(91)58(41(4)5)77-65(90)59(42(6)7)79(11)69(93)96-39-46-27-29-47(30-28-46)73-63(88)48(23-19-33-72-68(70)92)74-64(89)57(40(2)3)76-52(82)25-18-26-56(86)97-81-53(83)31-32-54(81)84/h15-17

Tyk2-IN-5 ino pyrazole is a activin receptor-like kinase-2Tyk2 IN 5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0. 086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFN. Highly effective in inhibiting IFN production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. Product information CAS Number: 1797432 62 2 Molecular Weight: 434. 43 Formula: C21H19FN8O2 Chemical Name: N [(1R,2S) 2 fluorocyclopropyl] 8