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PS48 was used at 5 µM concentration in cell culture
-20oC for 3 years
Identification and characterization of novel small-molecule protease-activated receptor 2 agonists
Formula: C20H23N3O3
reversible and selective inhibitor of human USP14 with an IC50 of 4
CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0216 PS48 was used at 5CP 690550, CAS No. 477600 75 2, is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3. 2 nM), JAK2 (IC50 ~4. 1 nM), and JAK3 (IC50 ~1. 6 nM). In cellular assays CP 690550 showed potent effects in the IL 2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM,
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