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It also seems that the synergism between predisposition to a certain HLA allele and polymorphism in drug metabolism is necessary to trigger DRESS, as in the case of patients with increased risk of reaction who are exposed to allopurinol, express HLA-B*58:01 and have decreased renal function, which leads to an increase in serum levels of allopurinol or its toxic metabolites.19 Immunological pathways There are several models by which the drug can stimulate the immune response and cause DRESS: (i) The hapten model, where antigen-presenting cells (APCs) and their HLA have a neoantigen to the TCR of a T nave cell through a strong covalent bond
Semolina is the most common type of pasta for a classic pasta salad, but if you want to add some whole grains to your summer pasta, why not go with a hearty whole-wheat pasta
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Ive used greek yogurt as the base of my dressing which gives it a lusciously creamy texture and no need for mayonnaise or raw eggs Is anchovy paste necessary in caesar salad dressing
