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22)/b12-8-
CPI-637 inhibits MYC expression in AMO-1 cells (EC50 = 0
while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction
Smiles: CC[C@]1(O)C2C=C3C4=NC5=CC=CC=C5C=C4CN3C(=O)C=2COC1=O
is a MRCK inhibitor
ML314 P-6 22)/b12-8-ML 314 is a brain penetrant nonpeptidic arrestin biased ggonist of the neurotensin NTR1 receptor, which exhibits full agonist behavior against NTR1 (EC50 = 2. 0 M) in the primary assay and selectivity against NTR2. The effect of ML314 is blocked by the NTR1 antagonist SR142948A in a dose dependent manner. Unlike peptide based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay and is thus a biased agonist that activates the
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