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1533426-90-2 (SCR7 potassium)
and SW480 cancer cells with IC50 values of 0
IC87114 (10 µM) inhibits both constitutive and Flt-3-stimulated Akt phosphorylation and cell proliferation
[Cardiovascular pharmacology of cinepazide
2002 Nov-Dec
VER-49009 Size:Solid 10 mg 1533426-90-2 (SCR7 potassium)VER 49009 is a potent HSP90 inhibitor. VER 49009 inhibits Hsp90 with an IC50 value of 47 nM. VER 49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER 49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C RAF, B RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. Product information CAS Number: 558640 51
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