2-Methoxyestradiol Size:10mg solid 21(9):1513-23

21(9):1513-23

4-dimethylbenzoate dimethanesulfonate

Mubritinib displays no inhibitory activities against PC-3 cells with HER2 expressed very faintly with IC50 of 4

and a 25-fold increase in GBM cell apoptosis in vivo

2015 Dec 18

2-Methoxyestradiol Size:10mg solid 21(9):1513-232 methoxyestradiol, also known as 2 ME, is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2 Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation,