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NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride Regorafenib monohydrate is a multi-target

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Description

Regorafenib monohydrate is a multi-target inhibitor for VEGFR1/2/3

CAS Number: 1092578-46-5

Epigenetics Chromatin

Smiles: CCCNC1C=CC2=NC=C(C3C=CN=CC=3)N2N=1

AG14361 is at least 1000-fold more potent than the benzamides

NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride Regorafenib monohydrate is a multi-targetTAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF IR with potential anticancer activity. TAE226 can block FAK and IGF IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration dependent decrease in cellular proliferation with an associated G(2) cell cycle

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