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KRN633 was well tolerated and had no significant effects on body weight or the general health of the animals
34(49)31(47)29(22)40(43
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape
087 mL/min/mg protein
InChiKey: MIIIKWNQFDQJGS-GIJPFRRLSA-N
T0070907 - CAS# 313516-66-4 Size:Solid 2 mg KRN633 was well tolerated andT0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2. T0070907 blocked PPARgamma function in both cell based reporter gene and adipocyte differentiation assays. T0070907 is a novel tool for the study of PPARgamma RXRalpha
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