Sulindac sulfone Size:Contact [email protected] for quotation InChi: InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4

InChi: InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4

Solubility: DMSO 10 mg/mL (30

6-tetrahydro-2

23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12

apoptosis and enhanced sensitivity to ionizing radiation

Sulindac sulfone Size:Contact [email protected] for quotation InChi: InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4Sulindac sulfone is a metabolite of the nonsteroidal anti inflammatory drug (NSAID) sulindac. In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA 7 cells with an IC50 of 360 mmol L. Sulindac sulfone at 100 mmol L reduced 6 ketoPGF by 29. 2%. Sulindac sulfone reduced the colony number of HCA 7 and HCT 116 with an EC50 of 50 mmol l. Sulindac sulfone significantly decreased the expression of total cellular catenin (50% of control),