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selective and cell-permeable class IIa HDAC inhibitor with IC50 of 126 nM
Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair
PubMed Central PMCID: PMC4846959
Formula: C21H16ClF3N4O3
InChi: InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28
K-7174 Size:Solid 2 mg selective and cell-permeable class IIaK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product
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