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supernatants from 3-O-C12-HSL-stimulated cells induced neutrophil chemotaxis
and decreases interleukin-1beta production by peritoneal macrophages
CAS Number: 484-29-7
Smiles: OB(O)C1=CC(COC2C=CC(C=C3SC(=O)N(CC4C=CC(F)=CC=4)C3=O)=CC=2)=CC=C1
inhibits tubulin polymerization
PC-766B Catalog No.:M22658-C supernatants from 3-O-C12-HSL-stimulated cells inducedPC 766B is a macrolide antibiotic existed in anactinomycete strain SC 4710. PC 766B was active against Gram positive bacteria, and some fungi and yeasts, yet inactive against Gram negative bacteria. PC 766B exhibited potent cytotoxicity against murine tumor cell lines in vitro. The IC50 values against P388 leukemia and B16 melanoma were 0. 1 and 0. 5 ng ml, respectively . Intraperitoneal administration of PC 766B (0. 25mg kg day) showed in vivo