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⁸]tetradeca-1(14)
PF-06447475 successfully blocks the enhanced neuroinflammation associated with G2019S-LRRK2 expression
Smiles: CNC(=O)C1C=CC(=CC=1)NC1=NC(NCC2=NC=CN=C2N(C)S(C)(=O)=O)=C(C=N1)C(F)(F)F
IC50 Value: 10±0
Formula: C45H45BrN6O10S
Lovastatin ndolapril ⁸]tetradeca-1(14)Lovastatin inhibits HMGCR, blocking the enzyme catalyzed transformation of 3 hydroxy 3 methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts