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Smiles: CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC2=C(C=N1)C(=O)N(CC=C)N2C1=CC=CC(=N1)C(C)(C)O
It inhibits 15-PGDH with noncompetitive pattern
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
potent and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A
MDK83190 has CAS#79183-19-0
BMS-708163 (Avagacestat) - γ-Secretase Inhibitor. CAS# 1146699-66-2 B-PNP Smiles: CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC2=C(C=N1)C(=O)N(CC=C)N2C1=CC=CC(=N1)C(C)(C)OBMS 708163 (Avagacestat), CAS No. 1146699 66 2, is a potent, selective and orally bioavailable secretase inhibitor with an IC50 of 0. 3 nM for APP cleavage. It is 190 fold more selective for APP than Notch, having an IC50 of 58 nM for Notch. Phase I clinical trial studies showed that in humans, BMS 708163 decreased CSF A40 and A42 approximately 30% following daily dose of 100 mg after 28 days and by 60% at daily dose of 150 mg. Product information CAS
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