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Chemical Name: (2S)-2-amino-5-carbamimidamidopentanoic acid
Sortin1 is a sorting inhibitor
Salirasib reduces Rheb in TSC2-null cells and TSC2 expression rescues the cells from the inhibitory effect of Salirasib
PubMed Central PMCID: PMC4007851
OTS514 exhibits growth suppressive effect on small cell lung cancer
BI-D1870 - CAS# 501437-28-1 Catalog No.:M11147-2 Chemical Name: (2S)-2-amino-5-carbamimidamidopentanoic acidBI D1870 is a potent and specific RSK inhibitor (the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 1030 nM. BI D1870 exhibited a dose responsive antiproliferative effect on OSCC cells with relative sparing of normal human oral keratinocytes. The compound inhibited the downstream RSK target YB 1 and caused apoptosis. In addition, BI D1870 also induced G2 M arrest by modulating the expression of p21 and
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