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24)20-11-4-6-21(7-5-11)16(22)10-19-14-9-13(18)12(17)8-15(14)25-2/h3
(2012) Nature Reviews Drug Discovery 11
RN-1 was used at 1 µM in vitro
eIF2α phosphorylation is also implicated in memory consolidation
InChi: InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H
PR-619 - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 2645-32-1 268 24)20-11-4-6-21(7-5-11)16(22)10-19-14-9-13(18)12(17)8-15(14)25-2/h3PR 619, CAS No. 2645 32 1, is a cell permeable, non selective, reversible broad range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1 20 M. PR 619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose and time dependent manner (20 to 150 M, 0. 5 to 20 h) without direct impairment of proteasomal proteolysis. PR 619 treatment results in upregulation of both K48 and K63 linked polyUb chains. It induces
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