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InChiKey: BYMOGFTUZUEFHY-SIUCFGLGSA-N
Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer
Nurmemmedov E
with IC50 values of between 2
InChi: InChI=1S/C28H27F3N6O2S/c1-2-36-10-12-37(13-11-36)16-20-6-7-21(15-22(20)28(29
MK-0354 497 InChiKey: BYMOGFTUZUEFHY-SIUCFGLGSA-NMK 0354 is a partial agonist of GPR109a receptor, for hGPR109a mGPR109a with EC50 of 1. 65 1. 08 M, showed no activation of GPR109b. IC50 value: 1. 65 M (EC50, for hGPR109a), 1. 08 M (EC50, for mGPR109a) Target: GPR109ain vitro: MK 0354 demonstrated clear and statistically significant partial agonism in the cAMP assays for both the mouse and human receptors with efficacy approximately 60 70% of that of either nicotinic acid or hydroxy butyrate, a
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