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LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP It is inactive to PKCμ

SKU: 21097077502

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Description

It is inactive to PKCμ

It can inhibit EGFR and Her2 phosphorylation

Purity: ≥98% for each compound Storage: 4oC for 3 month

It also down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo

04] in exponentially growing DNA-PK proficient but not deficient cells

LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP It is inactive to PKCμLLY 507, CAS No. 1793053 37 8, is a potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor with IC50 <15 nM. It binds in the substrate peptide binding pocket. It has >100 fold selectivity over other methyltransferases and other non epigenetic targets. LLY 507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. It inhibited the proliferation of several esophageal, liver, and breast cancer cell

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