ML-7 Hydrochloride - CAS# 110448-33-4 curcumin 2 nM for EGFR

2 nM for EGFR

>100 fold selectivity for p110α over other class-I PI3K isoforms

irreversibly alkylate Cys-773

PubMed PMID: 26268695

Girasole G

ML-7 Hydrochloride - CAS# 110448-33-4 curcumin 2 nM for EGFRML 7 is a MLCK inhibitor. ML 7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0. 3 M. ML 7 amplifies the quinocetone induced cell death through akt and MAPK mediated apoptosis on HepG2 cell line. ML 7 inhibits exocytosis of superoxide producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase independent manner. Product information CAS Number: 110448 33