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2-Ethyl-5, 7-dimethyl-3H-imidazo[4, 5-b]pyridine 7632 hydrochloride 17(12):1282-94

SKU: 22263200598

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Description

17(12):1282-94

PubMed PMID: 21966423

PF-8380 exposures estimated by area under the curve are approximately proportional to dose and linear up to 100 mg/kg

6-bis[(pyrrolidin-1-yl)methyl]cyclohexa-2

CAS Number: 52152-93-9

2-Ethyl-5, 7-dimethyl-3H-imidazo[4, 5-b]pyridine 7632 hydrochloride 17(12):1282-942 Ethyl 5,7 dimethyl 3H imidazo[4,5 b]pyridine is a nonpeptidic angiotensin II receptor antagonist. Angiotensin II is the critical pressor substance of the renin angiotensin system (RAS). The angiotensin II system, a proteolytic cascade regulating hemodynamics and water and electrolyte balance, is able to contribute to hypertensive states in human. The effects of the octapeptide angiotensin I1 includs cardiac stimulation, vasoconstriction, stimulation

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