Raloxifene 4'-glucuronide 11377 Chemical Name: 5-chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide

Chemical Name: 5-chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide

Epub 2017 Sep 5

InChiKey: HGWLTZOMQZIUBW-UHFFFAOYSA-N

and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide

Formula: C24H27Cl2FN6O

Raloxifene 4'-glucuronide 11377 Chemical Name: 5-chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamideRaloxifene 4' glucuronide is a primary metabolite of Raloxifene. Raloxifene 4' glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4' glucuronide binds to estrogen receptor with an IC50 of 370 M. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGF3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element containing vitellogenin promoter expression. Product