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PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies
Formula: C11H8O2
9-tetramethyldocosahydrospiro[naphtho[2'
absorption=546
ARV-771 results in suppression of both AR signaling and AR levels and leads to tumor regression in a CRPC mouse xenograft model
AG-636 217903 PIM kinases are downstream effectorsAG 636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. Differential AG 636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model. Dissection of the relationship between uridine availability and response to AG 636 revealed a divergent ability of lymphoma and solid tumor cell lines to survive and grow in the setting of depleted
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