PF-06305591 206Cyclodextrin Na/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2

Na/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2

HOKU-81 was approximately 8 times more potent than tulobuterol

) significantly inhibits the histamine-evoked paw edema

PHA-767491 directly counteracted the 5-FU-induced phosphorylation of Chk1

selective inhibitor of the tropomyosin-related kinase (TRK) family receptors

PF-06305591 206Cyclodextrin Na/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2PF 06305591 is a potent and highly selective voltage gated sodium channel NaV1. 8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile. Product information CAS Number: 1449473 97 5 Molecular Weight: 274. 36 Formula: C15H22N4O Chemical Name: (2R,3S) 3 amino 3 (5 tert butyl 1H 1,3 benzodiazol 2 yl) 2 methylpropanamide Smiles: C[C@H]([C@H](N)C1NC2=CC=C(C=C2N=1)C(C)(C)C)C(N)=O InChiKey: APWZIFIAVVFPNT PELKAZGASA N