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50 uM/20uM compound concentration's inhibitory percentage are 98%/92% for chitinase/N- acetyl-hexosaminidase respectively
Molecular Weight: 1347
Agomelatine enhances cell proliferation and neurogenesis in the ventral hippocampus (VH) of adult rats
Solubility: DMSO : 14 mg/mL (102
CC-115 shows good in vivo PK profiles across multiple species with 53%
PF-06463922 5109 HCl 50 uM/20uM compound concentration's inhibitoryLorlatinib, also known as PF 06463922, is an orally available, ATP competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, ALK ROS1 inhibitor PF 06463922 binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK and ROS1 mediated signaling and eventually inhibits tumor cell growth in ALK and
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