PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid Smiles: CC(=O)C1C=CC(=CC=1)NC(=O)C=CC1=CC=C(CC)O1

Smiles: CC(=O)C1C=CC(=CC=1)NC(=O)C=CC1=CC=C(CC)O1

Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b

Roy M Pollock

PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid Smiles: CC(=O)C1C=CC(=CC=1)NC(=O)C=CC1=CC=C(CC)O1PP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.