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The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta
Formula: C22H17ClN2
the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors
with Ki of 0
alpha-Tocopherol phosphate
Eprodisate Sodium - CAS# 36589-58-9 Catalog No.:M11419-10 The ALK-5 inhibitor A-83-01 inhibitsEprodisate, also known as 3 PDS; NC 503; 3PDS, is an orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan amyloid fibril aggregate. This prevents the formation