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2HX2OJH78L
InChi: InChI=1S/C23H20ClN3O/c1-15-7-8-16(2)22(11-15)27-14-26-20-12-17(9-10-21(20)27)23(28)25-13-18-5-3-4-6-19(18)24/h3-12
The highly polar carboxylate group of KDM5-C49 restricts its cellular permeability
Constitutively activated mutant FLT3 has emerged as a promising target for therapy for the subpopulation of acute myeloid leukemia (AML) patients who harbor it
Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)F
Trimethylamine N-oxide - CAS# 1184-78-7 60140 2HX2OJH78LTrimethylamine N oxide, CAS No. 1184 78 7, is a gut microbe dependent metabolite of dietary choline and other trimethylamine containing nutrients. Trimethylamine N oxide induces inflammation by activating the ROS NLRP3 inflammasome. Trimethylamine N oxide also accelerates fibroblast myofibroblast differentiation and induces cardiac fibrosis by activating the TGF smad2 signaling pathway. Product information CAS Number: 1184 78 7 Molecular Weight: 75.
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