K-252a - CAS# 99533-80-9 60261 as well as CXCR4 expression

as well as CXCR4 expression in WM cells

It referred to as an uncoupling agent because it disrupts ATP synthesis by transporting hydrogen ions through a cell membrane before they can be used to provide the energy for oxidative phosphorylation

is a potent and selective allosteric inhibitor of oncogenic K-Ras(G12C)

The mean IC50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines[1]

PMID: 33012874

K-252a - CAS# 99533-80-9 60261 as well as CXCR4 expressionK 252a, CAS No. 99533 80 9, also known as SF 2370, is an alkaloid isolated from Nocardiopisis bacteria. This staurosporine analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1. 8 and 1. 7 nmol L, respectively). At higher concentrations it is also an efficient inhibitor of serine threonine protein kinases (IC50 of 10 to 30 nmol L). Product information CAS Number: 99533 80 9 Molecular Weight: 467. 47