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RS-127445 administered at 1 to 10 mg/kg with oral significantly inhibits visceral hypersensitivity up to 35 to 74% provoked by restraint stress
endorsed by the Working Group on Heart Failure of the Portuguese Society of cardiology
Batchelor LA
In competition binding experiments on human recombinant mGlu5
Pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma
LTI-291 - CAS# 1919820-28-2 267 RS-127445 administered at 1 toLTI 291, CAS No. 1919820 28 2, is a glucocerebrosidase (Gcase) activator for treatment of Parkinson's disease (PD). Product information CAS Number: 1919820 28 2 Molecular Weight: 358. 48 Formula: C20H30N4O2 Synonym: LTI 291 LTI 291 LTI291 Chemical Name: 5,7 Dimethyl pyrazolo[1,5 a]pyrimidine 3 carboxylic acid (trans 4 pentyloxy cyclohexyl) amide Smiles: CCCCCO[C@@H]1CC[C@H](CC1)NC(=O)C1C=NN2C=1N=C(C)C=C2C InChiKey: HZILSILAELSWKN QAQDUYKDSA N InChi: