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Chemical Name: 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
Civallero M
Smiles: CN1CCN(CC1)C1=CC=C(C=N1)C1=CC(=C2C(=C1)N(C=C2C)C(C)C)C(=O)NCC1C(=O)NC(C)=CC=1C
which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death
Chemical Name: 5-chloro-3-[4-methanesulfonyl(2
WH-4-023 denafil Hydrochloride Chemical Name: 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolineWH 4 023 is a potent and selective dual Lck Src inhibitor with IC50 of 2 nM 6 nM for Lck and Src kinase respectively. The lymphocyte specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Product
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