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ROC-325 - CAS# 1859141-26-6 size:2mg solid is a potent and selective

SKU: 29974086236

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Description

is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2)

PubMed PMID: 8826855

InChi: InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9

Sarah Bethune

Berishaj M

ROC-325 - CAS# 1859141-26-6 size:2mg solid is a potent and selectiveROC 325, CAS No. 1859141 26 6, is an autophagy inhibitor. ROC 325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC 325 antagonized RCC growth and survival in an ATG5 7 dependent manner, induced apoptosis, and exhibited favorable selectivity. Product information CAS Number: 1859141 26 6 Molecular Weight: 503. 06

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