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Discovery of CP-690
1996 Feb 23
6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog
CCOC1C=CC(CC2=CC(=CC=C2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=CC=1
It is found in Acremonium chrysogenum
Folinic acid (calcium salt pentahydrate) relin Discovery of CP-690Leucovorin calcium is a n active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of
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