K-Ras ligand-Linker Conjugate 5 G 149 25)/b6-1-/t10-

25)/b6-1-/t10-

Solubility: DMSO: ≥ 100 mg/mL (80

Formula: C52H59ClN6O7

Smiles: CN(C)C[C@@H](NC(=O)N1CC2C(NC(=O)C3C=CC(=CC=3)NC(=O)C=C)=NNC=2C1(C)C)C1C=CC=CC=1

Butein (2 mg/kg every 2 days) in combination with Cisplatin (2 mg/kg every 2 days) for 3 weeks suppresses tumor growth in vivo

K-Ras ligand-Linker Conjugate 5 G 149 25)/b6-1-/t10-K Ras ligand Linker Conjugate 5 incorporates a ligand for K Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K Ras ligand Linker Conjugate 5 can be used in the synthesis of PROTAC K Ras Degrader 1 (HY 129523), which is potent PROTAC K Ras degrader that exhibits 70% degradation efficacy in SW1573 cells. Product information CAS Number: 2378261 85 7 Molecular Weight: 789. 96 Formula: C42H59N7O8