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EX-527 was administered by intracerebroventricular injection to rats at 5-10 µg to increase hypothalamic acetyl-p53 levels by inhibiting hypothalamic SIRT1 activity (formulation: dissolved in DMSO in a total volume of 5 μL)
the injected MTU (142 or 284 μg/kg) results in a maximum concentration of 10 or 20 μM in the peripheral blood
Vet Dermatol
PubMed Central PMCID: PMC4164785
Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that has now been withdrawn over safety concerns
Bis-PEG5-acid - CAS# 439114-13-3 nsin sodium salt(Coban) EX-527 was administered by intracerebroventricularBis PEG5 acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis PEG5 acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20. Product information CAS Number: 439114 13 3 Molecular Weight: 338. 35 Formula: C14H26O9 Synonym: PROTAC Linker 36 Chemical Name: 4, 7, 10, 13, 16 pentaoxanonadecanedioic acid Smiles: OC(=O)CCOCCOCCOCCOCCOCCC(O)=O InChiKey:
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