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Smiles: CN1CCN(CC1)C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C21
with IC50 and KD values close to or below 1 nM as well as a slow dissociation rate
When LnCaP cells are pretreated with AKT-IN-VIII and then incubated with TRAIL
Formula: C35H49N11O9S2
InChi: InChI=1S/C13H26O4/c1-2-3-4-5-6-7-8-9-13(16)17-11-12(15)10-14/h12
Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride Smiles: CN1CCN(CC1)C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C21Sorafenib, also known as BAY 43 9006, is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF MEK ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR 2 PDGFR beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer. Product
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