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including down-regulating retinoblastoma protein (pRB)
ML-193 (5 μM
(2003) Blood
6-²H₈)piperazin-1-yl]propyl}-10H-phenothiazine
2-a]pyrimidin-7-yl)-2-methoxypyridin-3-yl)-2
ZJ 43 60075 including down-regulating retinoblastoma protein (pRB)IC50: 2. 4 nM ZJ 43 is a N acetylaspartylglutamate (NAAG) peptidase inhibitor. The peptide neurotransmitter N acetylaspartylglutamate (NAAG) is reported to act as an agonist at group II metabotropic glutamate receptors. NAAG is inactivated by extracellular peptidase activity leading to yielding glutamate and N acetylaspartate. In vitro: As a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III) with Kivalues of 0. 8 and 23 nM
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