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6-24 hours) KRAS G12C degradation modulates Erk signaling in homozygous and heterozygous KRAS mutant cell lines
2017 Jul 31
SNAP 94847 (oral gavage
and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration
N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2
(3S, 5S)-Atorvastatin (sodium salt) yl-(3' 5')-guanosine 6-24 hours) KRAS G12C degradationAtorvastatin exists in four optical forms. The (3R, 5R) atorvastatin enantiomer displays the greatest activity against HMG CoA reductase. (3S,5S) Atorvastatin is an enantiomer of atorvastatin with little or no inhibitory activity against HMG CoA reductase . Atorvastatin is a synthetic HMG CoA reductase inhibitor implicated in lowering plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. Atorvastatin also reduces triglyceride
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