GX-674 2592 CAS Number: 173904-50-2

CAS Number: 173904-50-2

This small molecular could also transcriptionally up-regulates the expression of p53-responsive gene and induces the activation of caspases 3 and 7

CAS Number: 53678-77-6

1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide

InChiKey: GISRWBROCYNDME-PELMWDNLSA-N

GX-674 2592 CAS Number: 173904-50-2GX 674 is an aryl sulfonamide class of antagonists that inhibits Nav1. 7 Nav (voltage gated sodium) channels conduct ionic currents that initiate action potentials in neurons and muscles cells. Human express 9 Nav channel isoforms (Nav 1. 1 1. 9), among which Nav 1. 7 channel are express in olfactory epithelium, sympathetic ganglion, and dorsal root ganglion sensory neurons. Gain of function mutations in Nav1. 7 are associated with extreme pain