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m-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs
Smiles: CCC(C)C(NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C(N)CCCCN)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(O)=O
Chemical Name: 2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid
a potent chelator of iron
CC(C)C1=C(C(=C(C2C=CC(F)=CC=2)N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1C=CC=CC=1)C(=O)NC1C=CC=CC=1
PF-3450074 60276 m-PEG3-SH is a PEG-based PROTACPF 3450074 (PF 74) is a specifical inhibitor of HIV 1 capsid protein (CA) and displays a broad spectrum inhibition of HIV isolates with submicromolar potency (EC50=8 640 nM). PF 3450074 (PF 74) acts at an early stage of HIV 1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors
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