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PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine
InChi: InChI=1S/C40H69N11O14S/c1-20(2)13-26(36(60)43-15-30(54)45-23(6)34(58)46-22(5)33(57)42-16-32(56)48-27(40(64)65)14-21(3)4)49-38(62)29-9-8-11-51(29)39(63)25(10-12-66-7)47-31(55)17-44-37(61)28(19-53)50-35(59)24(41)18-52/h20-29
increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000
CAS Number: 138489-18-6
SKA-121 exhibits EC50s of 109 nM and 4
Pladienolide B 427Arg)9 PU 23 is a non-carboxylicPladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre mRNA splicing. Pladienolide B induces apoptosis. Product information CAS Number: 445493 23 2 Molecular Weight: 536. 70 Formula: C30H48O8 Chemical Name: (2S,3S,6S,7R,10R) 7,10 dihydroxy 2 [(2E,4E,6S) 7 [(2R,3R) 3 [(2R,3S) 3 hydroxypentan 2 yl]oxiran 2 yl] 6
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