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Delivering CWHM 12 or a similar small molecule directly into the lungs as an inhalant might offer a way to treat lung fibrosis
Nabeshima R
Epub 2015 Dec 31
2000 May 12
CN1CCN(CC1)[C@@H]1CC[C@H](CC1)N1C=C(C2=C(N)N=CN=C12)C1C=CC(=CC=1)OC1C=CC=CC=1
cGAMP Size:Solid 10 mg Delivering CWHM 12 or aCyclic AMP GMP, also known as cGAMP, is one of several naturally occurring cyclic dinucleotides that act as a bacterial second messengers to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. In cholera c AMP GMP promotes intestinal colonization by down regulating chemotaxis. During infections bacterial cGAMP is bound by host STING
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