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Smiles: O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CCl
CAS Number: 55368-40-6
23(3):274-6
1092351-67-1
The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
MC1568 - Class IIa HDAC Inhibitor. CAS# 852475-26-4 0318 Smiles: O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CClMC1568, CAS No. 852475 26 4, is a potent and selective inhibitor of class IIa histone deacetylases (HDACs), with IC50 of 100 nM for maize HD1 A. It is 34 fold more selective for HD1 A than HD1 B, 176 fold more selective for class I HDACs. It exhibits tissue selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. It arrests myogenesis through the
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