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VU 0119498
InChiKey: WCAATDGMINWXPJ-BTJKTKAUSA-N
Smiles: CC1=NC=C(C=C1C1=CC(OC)=C(OC)C(=C1)OC)C1C=CC(=CC=1)N1CCNCC1
CAS Number: 1802326-66-4
Left ventricular hypertrophy
ON-01910 selective p38α PROTAC VU 0119498ON 01910 is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo like kinase 1 inhibitor ON 01910. Na inhibits polo like kinase1 (Plk1), inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents.
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