T-448 hoxymethyl) ethanol InChi: InChI=1S/C35H37FN6O5/c1-40-14-16-41(17-15-40)13-6-18-46-34-21-27-25(20-33(34)45-3)30(11-12-37-27)47-31-10-9-24(19-26(31)36)39-35(43)28-22-42(23-38-28)29-7-4-5-8-32(29)44-2/h4-5

Name: T-448 hoxymethyl) ethanol InChi: InChI=1S/C35H37FN6O5/c1-40-14-16-41(17-15-40)13-6-18-46-34-21-27-25(20-33(34)45-3)30(11-12-37-27)47-31-10-9-24(19-26(31)36)39-35(43)28-22-42(23-38-28)29-7-4-5-8-32(29)44-2/h4-5
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Description

InChi: InChI=1S/C35H37FN6O5/c1-40-14-16-41(17-15-40)13-6-18-46-34-21-27-25(20-33(34)45-3)30(11-12-37-27)47-31-10-9-24(19-26(31)36)39-35(43)28-22-42(23-38-28)29-7-4-5-8-32(29)44-2/h4-5

InChiKey: NODGUBIGZKATOM-UHFFFAOYSA-N

7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway

Using the scratchwound model

43)/b23-20-/t29-/m0/s1

T-448 hoxymethyl) ethanol InChi: InChI=1S/C35H37FN6O5/c1-40-14-16-41(17-15-40)13-6-18-46-34-21-27-25(20-33(34)45-3)30(11-12-37-27)47-31-10-9-24(19-26(31)36)39-35(43)28-22-42(23-38-28)29-7-4-5-8-32(29)44-2/h4-5T 448 is a specific, orally active and irreversible inhibitor of lysine specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T 448 enhances H3K4 methylation in primary cultured rat neurons. Product information CAS Number: 1597426 53 3 Molecular Weight: 444. 50 Formula: C21H24N4O5S Chemical Name: (2E) but 2 enedioic acid; 3 [(1R,2S) 2 (cyclobutylamino)cyclopropyl] N (5 methyl 1,3,4 thiadiazol 2 yl)benzamide Smiles:

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