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7a-hexahydro-1
PubMed Central PMCID: PMC4651225
Int J Clin Exp Pathol
CAS Number: 627908-92-3
CAS Number: 1031063-36-1
Nexturastat A utidine 7a-hexahydro-1Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5. 02 + 0. 60 nM). Nexturastat A possesses antiproliferative effects against melanoma cells. Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation can lead to the development of cancers. There is renewed interest in capitalizing