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InChi: InChI=1S/C14H12O3/c1-8(2)12-7-10-11(16-12)5-3-9-4-6-13(15)17-14(9)10/h3-6
5 mg/mL (45
targets mutant FLT3 and is currently in late-stage clinical trials
11-19)14-3-1-12(2-4-14)13-9-20-21-10-13/h1-10
which is a potent 5-HT3 and 5-HT4 receptor dual antagonist
ATC 0175 hydrochloride 2927 InChi: InChI=1S/C14H12O3/c1-8(2)12-7-10-11(16-12)5-3-9-4-6-13(15)17-14(9)10/h3-6ATC0175 hydrochloride is a potent, selective and orally active antagonist of melanin concentrating hormone receptor 1 (MCH1) with IC50 of 13 nM for MCH1. It was also shown to have affinity for 5 HT2B and 5 HT1A receptors with IC50 of 9. 66 nM and 16. 9 nM respectively. Melanin concentrating hormone receptor (MCH1), a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. The
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