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3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2
Nakamura T
Martinier N
also known as Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11
Dalcetrapib achieves 50% inhibition of CETP activity in human plasma at a concentration of 9 μM
PND-1186 Catalog No.:M9572-2 3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2PND 1186, also known as SR 2156 and VS 4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1. 5 nM in vitro. PND 1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1. 0 M PND 1186 (>5 fold above IC50) had limited effects on cell proliferation. However, under non adherent conditions as spheroids and as colonies in soft agar, 0. 1 M PND 1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase 3